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These protective effects were absent in GLP-1R deficient (Glp1r^Wnt1/) mice, highlighting the critical role of neuronal GLP-1R signaling in mediating the anti-inflammatory and organ-protective actions of GLP-1RAs in sepsis (56)

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Although IGF1 was not associated with overall colorectal cancer risk, it appears to be associated with the increased risk for advanced colorectal cancer [5]

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Mol Cell Endocrinol 203 : 5163 LeRoith D, Baserga R, Helman L, Roberts Jr CT (1995a) Insulin-like growth factors and cancer